Elucidating an uncommon disease inflammatory breast cancer
Bilateral breast involvement was found in 3 patients.
The IBC cases were identified from the department of pathology of Saleh Azaiz Cancer Institute in Tunis from all T4D patients with diagnostic tissue biopsies of patients diagnosed as IBC from the surgical and medical oncology departments at the institute during the period of 2007–2008.The American Joint Committee on Cancer (AJCC) diagnostic criteria of IBC require that erythema must involve at least 50% of the breast although some IBC do not fulfill this criterion. While ulceration can occur in rare IBC cases, it considered more indicative of neglected LABC and it is critical to accurately distinguish between these two diseases to ensure appropriate treatment .However, given the difficulty in distinguishing neglected LABC from IBC, the distinction is often difficult to make .Soliman, Department of Epidemiology, University of Nebraska Medical Center College of Public Health, 984395 Nebraska Medical Center, Omaha, NE 68198-4395, USA. We included 3 sets of patients from Egypt (48 IBC and 64 non-IBC), Tunisia (24 IBC and 40 non-IBC), and Morocco (42 IBC and 41 non-IBC).Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ±SD: 14.1 ± 14.0 vs. This study illustrates that Rho C overexpression and tumor emboli are more frequent in IBC relative to non-IBC from Egypt and Tunisia.